By John G. Bartlett
Designed to supply easy access to the criteria with which to struggle infectious affliction by way of concentrating on choice, right doses, charges, and unintended effects of antimicrobial brokers, the 2004 notebook of Infectious illness remedy attracts commonly from strategies made by means of the facilities for sickness keep an eye on, the scientific Letter, the yankee health center Formulary carrier, and the AMA's Drug reviews. Tabular fabric has been up to date to incorporate all newly authorized antibiotics, in addition to new thoughts for administration.
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Extra resources for 2004 Pocket Book of Infectious Disease Therapy
75 mg/kg/d Ketoconazole Usual regimen Usual regimen Lamivudine 25–50 mg/d dose postdialysis 25–50 mg/d Levofloxacin 500 mg, then 250 mg q48h 500 mg, then 250 mg q48h Linezolid Usual dose Usual dose Metronidazole Usual regimen Usual regimen Mezlocillin 2–3 g postdialysis then 3–4 g q12h 3 g q12h Minocycline Usual dose (some suggest reduced dose) Usual dose (some suggest reduced dose) Moxalactam 1–2 g postdialysis 1–2 g/d Moxifloxacin Usual dose Usual dose Nafcillin Usual regimen Usual regimen Netilmicin 2 mg/kg postdialysis Loading dose predialysis 3–5 mg/L dialysate* Ofloxacin 200 mg, then 100 mg q24h ?
C. Obese patients: Use lean body weight. d. Renal failure: Formulas assume stable renal function; for patients with anuria or oliguria assume creatine clearance (CCr) of 5–8 mL/min. B. AMINOGLYCOSIDE DOSING 1. 12 × CCr = mg/kg/8 h 20–40 Cg/mL a Doses for gentamicin and tobramycin should be written in multiples of 5 mg; doses of amikacin and kanamycin should be written in multiples of 25 mg. , 3 mg/kg for gentamicin and tobramycin. c Obese patients: use calculated lean body weight plus 40% of excess fat.
Metronidazole: Modify dose for severe hepatic failure, although specific guidelines are not provided; peak serum levels with 500 mg doses are 10–20 :g/mL. Mezlocillin: Reduce dose by 50% or double the dosing interval. Nafcillin: Metabolized by liver and largely eliminated in bile; nevertheless, dose modifications are suggested only for combined hepatic and renal failure. : Dose reduction for hepatic failure only when accompanied by renal failure. Ribavirin: AUC is unchanged wih severe hepatic failure.
2004 Pocket Book of Infectious Disease Therapy by John G. Bartlett